Alzheimer Disease - "earlyonset" and new therapies

NYTimes has a popular piece about an extended family, ravaged by early-onset (earlyonset) Alzheimer Disease and how a study using vaccines and anti-amyloidogenic medications is attempting to see whether early interventions might affect disease course.  Given how difficult the disease has been to treat thus far, I'm not terribly optimistic about the current studies.  But in order to get to the promised land of developing treatments that dramatically affect outcomes, sometimes the best researchers can do is continue to soldier on.  At the very least, new insights are sure to emerge...